What does the name levodopa mean
L-DOPA Powder is a drug commonly used to treat Parkinson's disease, and its chemical name is levodopa. Parkinson's disease will cause a decrease in the body's rate of movement, including tremors, muscle stiffness, and slow movements in the hands and extremities. Levodopa is a drug that relieves the symptoms of Parkinson's disease by increasing dopamine levels in the body.
In the human body, levodopa is converted into dopamine because levodopa is converted into dopamine by carboxylase in many parts of the central nervous system. Dopamine is a neurotransmitter that plays a vital role in the human body. In people with Parkinson's disease, levels of dopamine drop significantly, causing neurons not to function correctly. Then, the treatment plan of giving levodopa is to relieve the related symptoms by increasing the level of dopamine to mimic the nerve transmission process of ordinary people. These areas include the pituitary gland, substantia nigra, pineal gland, and prefrontal cortex. In the process of dopamine conversion, it will connect with the receptors of dopamine neurons, thereby increasing the activity of dopamine and improving the related nerve conduction process. At the same time, because levodopa can reach the brain through the blood-brain barrier, its therapeutic effect is pronounced. So if you need pure levodopa, you can contact Xi'an Sonwu online.
L-DOPA supplement benefits
1. Parkinson's disease
Parkinson's disease is a neurological disease characterized by dyskinesia and dysfunction, which can significantly affect the daily life of patients. By reducing the symptoms of Parkinson's disease, levodopa can improve patient's quality of life, allowing them to live and work more independently. Levodopa is converted to dopamine in the patient's body, thereby helping to relieve symptoms such as movement disorders, such as stiffness, tremors, and muscle weakness, caused by a lack of dopamine caused by neuronal loss. Since levodopa improves movement disorders in Parkinson's patients, it gives them better muscle control, reducing symptoms such as muscle pain and joint pain.
Effective levodopa treatment is the criterion for diagnosing Parkinson's disease. If levodopa is ineffective, it cannot be interpreted as primary Parkinson's disease. Therefore, levodopa supplementation is the most basic and effective treatment for Parkinson's disease. Only when it is effective can the primary Parkinson's disease be diagnosed? For others, such as Parkinson's syndrome, Kimson's superposition syndrome, and hereditary Parkinson's disease, the treatment effect of levodopa may be relatively poor.
2. Hepatic encephalopathy
Hepatic encephalopathy is a severe clinical condition commonly seen in patients with low liver function, including liver cirrhosis, hepatitis, and other diseases. This lesion causes toxins in the blood to accumulate in the body, which in turn affects the part of the brain, causing cognitive impairment, psychiatric symptoms, motor dysfunction, and possibly death. Hepatic encephalopathy is a comprehensive treatment, such as removing toxins in the body and improving liver function and nutritional support. The role of levodopa in this process is primarily manifested in the following aspects:
Ammonia toxemia is one of the leading causes of hepatic encephalopathy. Levodopa can reduce the ammonia level in the blood by inhibiting the synthesis of ammonia in the intestine, reducing the number of bacteria, and thereby reducing the symptoms of hepatic encephalopathy. Levodopa is often used in combination with dopamine decarboxylase inhibitors to treat Parkinson's disease to increase dopamine levels. Therefore, studies have shown that levodopa can increase the level of dopamine in patients with hepatic encephalopathy, thereby improving the patient's mental state and motor function. Levodopa can promote the regeneration of liver cells, thereby promoting the recovery of liver function. That is because after metabolizing levodopa into dopamine, it can increase bile acid synthesis, thereby improving the synthesis and excretion of bile by liver cells. Levodopa has a particular antioxidant effect, inhibiting the formation of free radicals and oxidative stress and reducing damage to liver cells. In addition, levodopa can also impede the occurrence of apoptosis in liver cells and protect liver function. Xi'an Sonwu, a manufacturer with more than ten years of manufacturing experience, can provide wholesale L-DOPA.
What is the mechanism of the effect of L-DOPA
Parkinson's disease is a syndrome caused by decreased dopamine neurons leading to a lack of dopamine. Under normal circumstances, dopamine neurons in the midbrain absorb tyrosine in the blood, generate dopamine under the action of tyrosine hydroxylase, and then produce dopamine through the activity of dopa decarboxylase, and store it in synaptic vesicles, Released to act on the postsynaptic membrane when the nerve sends out an impulse to work. Therefore, Mucuna Pruriens extract supplementation should be the most effective treatment for lacking dopamine. However, direct dopamine supplementation to patients has unfortunately failed to achieve efficacy. That is because there is a biological barrier between blood and brain tissue - the blood-brain barrier, and dopamine cannot directly pass through this barrier. Later, it was found that levodopa, the precursor of dopamine, can pass through the blood-brain barrier and be converted into dopamine through the action of dopa decarboxylase, thereby playing a therapeutic role.
After entering the body, levodopa is transported into the blood through the amino acid pump in the small intestine. The decarboxylase in the intestinal wall decarboxylates more than two-thirds of the levodopa, and the dopa decarboxylase in the blood degradation metabolizes 95% of the levodopa entering the blood. Therefore, the treatment of levodopa is alternative or supplementary.
What are the side effects of levodopa
(1) Early side effects
Peripheral side effects: loss of appetite, nausea, vomiting, abdominal pain, orthostatic hypotension, angina, arrhythmia, myocardial damage, increased blood urea nitrogen, etc.
Central adverse reactions: insomnia, restlessness, delusions, hallucinations, and other mental disorders.
(2) Long-term treatment syndrome
1) Dyskinesia: The incidence rate is relatively high, and it is more common in patients who have been taking DA for several months to several years, and the treatment is effective. The user will experience chewing-like movements of the lips and jaw, accompanied by head and neck swinging back and forth, side to side, or irregular twisting, as well as involuntary head and face movements such as frowning, frowning, and tongue sticking out, which are called DA-induced mouth-tongue movements DA-induced limb movement disorder; and violent impact-like, dance-like or dystonia-like abnormal movements of the limbs, which often affect daily life such as standing up, eating, and writing.
2) Aggravation at the end of the dose or intraday fluctuation: the adequate time of each dose is shortened, the symptoms worsen 1-2 hours before the next dose, and the worsening symptoms disappear after retaking the medicine. Another manifestation is that when the concentration peaks after taking DA, there is a movement disorder, and when the DA concentration decreases, it turns into an inactive state.
3) On-off phenomenon: it is common in PD patients with significant curative effects and younger onset after taking large doses of DA. During the "off" phase, the symptoms suddenly aggravate or become less active temporarily. This phenomenon can last 10 minutes to several hours and suddenly become the "on" phase. That is, the symptoms suddenly return to a good state. In many patients, movement disorders occur when the switch state occurs.
4) The state of "frozen feet": When walking, eating, or talking, it is difficult to take the first step, hold the first chopsticks, or speak the first sentence, just like the frozen state.
L-DOPA dosage
The recommended dosage for Mucuna Pruriens, 98% levodopa, is 250 – 500 mg daily. Start with 250mg once, 2~4 times daily, and take after meals. Depending on the patient's tolerance, the dose will be increased every 3-7 days, and the increased range will be 125-750 mg per day until the best curative effect is achieved.
You may need to cycle levodopa only 4 or 5 days a week.
For levodopa, Xi'an Sonwu can offer powder and capsules. If you want to buy L-DOPA or have other questions about the product, please click on the mail, and Xi'an Sonwu will provide good suggestions or solve your problems.
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